As a non-medicinal product, Cura-Heat is safe to use in conjunction with oral pain relieving medication.  Cura-Heat should not be used over the same area as topical pain relieving medication.

There are many different Cura-Heat products available. Some can be applied directly to the skin and some should be applied over clothing/underwear. 

PLEASE READ EACH INDIVIDUAL PRODUCTS' INSTRUCTIONS FOR USE CAREFULLY PRIOR TO USE TO DETERMINE HOW IT SHOULD BE USED. NEVER USE A CLOTHING ADHESIVE TYPE HEAT PATCH DIRECTLY ON THE SKIN.